Hydrocortisone Iodoquinol Cream and Hepatic dysfunction

• Generic Name: hydrocortisone / iodoquinol topical
• Dosage Forms: cream
• Other Brand Names: Dermazene, Vytone

Principally used in combination with hydrocortisone for the topical treatment of subacute and chronic dermatoses.

National Research Council and FDA state that iodoquinol/hydrocortisone combinations are “possibly” effective for topical treatment of eczema (e.g., impetiginized eczema, nummular eczema, infantile eczema, nuchal eczema) and dermatitis (e.g., contact, atopic, endogenous chronic infectious, stasis, localized or disseminated neurodermatitis). Also may be effective for treatment of bacterial dermatoses, mycotic dermatoses [e.g., tinea (capitis, cruris, corporis, pedis), pyoderma, chronic eczematoid otitis externa, acne urticata, lichen simplex chronicus, anogenital pruritus (vulvae, scroti, ani), folliculitis, moniliasis, and intertrigo. .

Has been used topically in a suitable dermatologic vehicle alone or in combination with coal tar in the treatment of bacterial and fungal infections of the skin.

Has been used in the treatment of diaper rash (diaper dermatitis); however, use in children currently is not recommended. (See Pediatric Use under Cautions.)

Has been used as a shampoo (no longer commercially available in the US) for control of seborrheic dermatitis of the scalp; however, relapse usually occurs when the drug is discontinued.