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Hydrochlorothiazide and fosinopril and Liver impairment

Result of checking the interaction of drug Hydrochlorothiazide and fosinopril and disease Liver impairment for safety when used together.

Check result:

Hydrochlorothiazide and fosinopril <> Liver impairment

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Fosinopril is primarily metabolized by hepatic and gut wall esterases to its active moiety, fosinoprilat, patients with impaired liver function could develop elevated plasma levels of unchanged fosinopril. In a study in patients with alcoholic or biliary cirrhosis, the extent of hydrolysis was unaffected, although the rate was slowed. In these patients, the apparent total body clearance of fosinoprilat was decreased and the plasma AUC approximately doubled.

Hydrochlorothiazide and fosinopril

Generic Name: fosinopril / hydrochlorothiazide

Brand Name: Monopril HCT

Synonyms: Fosinopril and Hydrochlorothiazide

What is Hydrochlorothiazide and fosinopril?