Drug search by name

Guanabenz and Renal dysfunction

Result of checking the interaction of drug Guanabenz and disease Renal dysfunction for safety when used together.

Check result:

Guanabenz <> Renal dysfunction

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

The disposition of orally administered guanabenz is altered modestly in renal impairment. The manufacturer states that the plasma clearance of guanabenz is reduced and its half-life prolonged in patients with impaired renal function, and more so in those on hemodialysis. The clinical significance of these findings is unknown. Careful monitoring of blood pressure during dosage titration is recommended.

References:

Dubrow A, Mittman N, DeCola P, et al "Safety and efficacy of guanabenz in hypertensive patients with moderate renal insufficiency." J Clin Hypertens 1 (1985): 322-5
"Product Information. Wytensin (guanabenz)." Wyeth-Ayerst Laboratories, Philadelphia, PA.

Guanabenz

Generic Name: guanabenz

Brand Name:

Synonyms: Guanabenz (Oral)

What is Guanabenz?