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Aloprim and Renal dysfunction

Result of checking the interaction of drug Aloprim and disease Renal dysfunction for safety when used together.

Check result:

Aloprim <> Renal dysfunction

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Patients with decreased renal function require lower dosages of allopurinol than normal to control serum urate levels. Therapy should be initiated at reduced dosages with smaller incremental changes in such patients. Additionally, individuals with preexisting renal disease or poor urate clearance have demonstrated a rise in BUN during therapy with allopurinol. Renal failure has also been observed among some with hyperuricemia secondary to neoplastic diseases. Renal function should be monitored during the initial stages of therapy, and the dosage reduced or the drug withdrawn if necessary.

References:

Hande K, Reed E, Chabner B "Allopurinol kinetics." Clin Pharmacol Ther 23 (1978): 598-605
"Product Information. Zyloprim capsules (allopurinol)." Glaxo Wellcome, Research Triangle Park, NC.
Hande KR, Noone RM, Stone WJ "Severe allopurinol toxicity: description and guidelines for prevention in patients with renal insufficiency." Am J Med 76 (1984): 47-56

Aloprim

Generic Name: allopurinol

Brand Name: Aloprim, Zyloprim, Lopurin

Synonyms: n.a.

What is Aloprim?