Drug search by name

Acebutolol and Renal dysfunction

Result of checking the interaction of drug Acebutolol and disease Renal dysfunction for safety when used together.

Check result:

Acebutolol <> Renal dysfunction

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

The active metabolite of acebutolol, diacetolol, is eliminated primarily by the kidney. Patients with renal impairment may be at greater risk for adverse effects due to metabolite accumulation. Dosage adjustments are recommended for patients with moderate to severe renal dysfunction (CrCl < 50 mL/min).

References:

Kirch W, Kohler H, Berggren G, Braun W "The influence of renal function on plasma levels and urinary excretion of acebutolol and its main N-acetyl metabolite." Clin Nephrol 18 (1982): 88-94
Gabriel R "Acebutolol in the management of hypertension in patients with renal disease." Br J Clin Pract 33 (1979): 259-62
"Product Information. Sectral (acebutolol)." Wyeth-Ayerst Laboratories, Philadelphia, PA.
Roux A, Aubert P, Guedon J, Flouvat B "Pharmacokinetics of acebutolol in patients with all grades of renal failure." Eur J Clin Pharmacol 17 (1980): 339-48

Acebutolol

Generic Name: acebutolol

Brand Name: Sectral

Synonyms: n.a.

What is Acebutolol?