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Allopurinol Intravenous and Dehydration

Result of checking the interaction of drug Allopurinol Intravenous and disease Dehydration for safety when used together.

Check result:

Allopurinol Intravenous <> Dehydration

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Adequate hydration is necessary during therapy with allopurinol to prevent both the formation of xanthine calculi and renal precipitation of urates when concomitant uricosuric agents are given. Patients who are dehydrated (e.g., due to severe diarrhea or vomiting) may be at increased risk and should be encouraged to consume additional amounts of liquid or given intravenous fluid. In general, fluid intake sufficient to yield a daily urinary output of at least 2 liters is recommended. Maintenance of a slightly alkaline or neutral urine is also desirable.

References:

"Product Information. Zyloprim capsules (allopurinol)." Glaxo Wellcome, Research Triangle Park, NC.
McInnes GT, Lawson DH, Jick H "Acute adverse reactions attributed to allopurinol in hospitalized patients." Ann Rheum Dis 40 (1981): 245-9
Landgrebe AR, Nyhan WL, Coleman M "Urinary-tract stones resulting from the excretion of oxypurinol." N Engl J Med 292 (1975): 626-7
Stote RM, Smith LH, Dubb JW, Moyer TP, Alexander F, Roth JL "Oxypurinol nephrolithiasis in regional enteritis secondary to allopurinol therapy." Ann Intern Med 92 (1980): 384-5

Allopurinol Intravenous

Generic Name: allopurinol

Brand Name: Zyloprim, Lopurin, Aloprim

Synonyms: Allopurinol

What is Allopurinol Intravenous?