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Gemfibrozil and Renal dysfunction

Result of checking the interaction of drug Gemfibrozil and disease Renal dysfunction for safety when used together.

Check result:

Gemfibrozil <> Renal dysfunction

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

The use of gemfibrozil is considered by the manufacturer to be contraindicated in patients with severely impaired renal function. The rate of clearance of gemfibrozil may be decreased in such patients, with possible accumulation during chronic dosing. Increased adverse effects, including rhabdomyolysis (with or without secondary renal failure) and severe hyperkalemia, have been associated with the use of fibric acid derivatives in patients with renal insufficiency. Some patients, usually those with baseline plasma creatinine above 2.0 mg/dL, have also experienced a deterioration of renal function when treated with gemfibrozil. Therapy with gemfibrozil should be administered cautiously in patients with significant renal impairment. Reduced dosages and close clinical monitoring are recommended.

References:

Gorriz JL, Sancho A, Lopezmartin JM, Alcoy E, Catalan C, Pallardo LM "Rhabdomyolysis and acute renal failure associated with gemfibrozil therapy." Nephron 74 (1996): 437-8
Miller DB, Spence JD "Clinical pharmacokinetics of fibric acid derivatives (fibrates)." Clin Pharmacokinet 34 (1998): 155-62
Knauf H, Kolle EU, Mutschler E "Gemfibrozil absorption and elimination in kidney and liver disease." Klin Wochenschr 68 (1990): 692-8
Dealava E, Sola JJ, Lozano MD, Pardomindan FJ "Rhabdomyolysis and acute renal failure in a heart transplant recipient treated with hypolipemiants." Nephron 66 (1994): 242-3
"Product Information. Lopid (gemfibrozil)." Parke-Davis, Morris Plains, NJ.
Thompson CH, Irish A, Kemp GJ, Taylor DJ, Radda GK "Skeletal muscle metabolism before and after gemfibrozil treatment in dialysed patients with chronic renal failure." Clin Nephrol 45 (1996): 386-9
Pokroy N, Ress S, Gregory MC "Clofibrate-induced complications in renal disease: a case report." S Afr Med J 52 (1977): 806-8
Goldman JA, Fishman AB, Lee JE, Johnson RJ "The role of cholesterol-lowering agents in drug-induced rhabdomyolysis and polymyositis ." Arthritis Rheum 32 (1989): 358-9
Evans JR, Forland SC, Cutler RE "The effect of renal function on the pharmacokinetics of gemfibrozil." J Clin Pharmacol 27 (1987): 994-1000

Gemfibrozil

Generic Name: gemfibrozil

Brand Name: Lopid

Synonyms: n.a.

What is Gemfibrozil?