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Frovatriptan and Liver disease

Generic Name: frovatriptan
Dosage Forms: n.a.
Other Brand Names: Frova

Result of checking the interaction of drug Frovatriptan and disease Liver disease for safety when used together.

Check result:

Frovatriptan <> Liver disease

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Frovatriptan is primarily metabolized by the liver. Following oral administration in patients with mild (Child-Pugh 5-6) to moderate (Child-Pugh 7-9) hepatic impairment, the systemic exposure of frovatriptan was approximately twice that observed in young, healthy subjects but still considerably lower than the values attained with higher dosages of frovatriptan (up to 40 mg), which were not associated with any serious adverse effects. Dosage adjustments are not necessary in patients with mild to moderate hepatic impairment. Caution is advised in patients with severe hepatic impairment, as there are no clinical or pharmacokinetic data on the use of frovatriptan in this population.

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