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Flumazenil and Hepatic dysfunction

Result of checking the interaction of drug Flumazenil and disease Hepatic dysfunction for safety when used together.

Check result:

Flumazenil <> Hepatic dysfunction

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Flumazenil is a highly extracted drug, dependent on blood flow, and primarily metabolized by the liver. Hepatic clearance is decreased 40% to 60 % in patients with moderate hepatic dysfunction and 75% in patients with severe hepatic dysfunction. Care should be exercised as the metabolic and therapeutic activity of flumazenil may be altered in patients with compromised hepatic function or conditions that decrease systemic blood flow. Following the initial dose, subsequent doses or the frequency of administration should be reduced.

References:

Pomier-Layrargues G, Giguere JF, Lavoie J, Willems B, Butterworth RF "Pharmacokinetics of benzodiazepine antagonist Ro 15-1788 in cirrhotic patients with moderate or severe liver dysfunction." Hepatology 10 (1989): 969-72
"Product Information. Romazicon (flumazenil)." Roche Laboratories, Nutley, NJ.
Klotz U "Drug interactions and clinical pharmacokinetics of flumazenil." Eur J Anaesthesiol Suppl 2 (1988): 103-8
Janssen U, Walker S, Maier K, von Gaisberg U, Klotz U "Flumazenil disposition and elimination in cirrhosis." Clin Pharmacol Ther 46 (1989): 317-23
van der Rijt CC, Drost RH, Schalm SW, Schramel M "Pharmacokinetics of flumazenil in fulminant hepatic failure." Eur J Clin Pharmacol 41 (1991): 501
Roncari G, Ziegler WH, Guentert TW "Pharmacokinetics of the new benzodiazepine antagonist Ro 15-1788 in man following intravenous and oral administration." Br J Clin Pharmacol 22 (1986): 421-8

Flumazenil

Generic Name: flumazenil

Brand Name: Romazicon

Synonyms: n.a.

What is Flumazenil?