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Fludara and Myelosuppression

Result of checking the interaction of drug Fludara and disease Myelosuppression for safety when used together.

Check result:

Fludara <> Myelosuppression

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Fludarabine can severely suppress bone marrow function. Leukopenia, thrombocytopenia, and anemia have been reported during fludarabine therapy. Patients should be instructed to immediately report any signs or symptoms suggesting bone marrow suppression such as fever, sore throat, local infection, or bleeding. Therapy with fludarabine should be administered cautiously in patients with bone marrow suppression. Close clinical monitory of hematopoietic function is recommended.

References:

Keating MJ, Estey E, O'Brien S, Kantarjian H, Robertson LE, Plunkett W "Clinical experience with fludarabine in leukaemia." Drugs 47 Suppl 6 (1994): 39-49
Woodcock BE "Cytopenia and fludarabine." Lancet 342 (1993): 1049
Zinzani PL, Tabanelli M, Bendandi M, Tura S "Prolonged bone marrow aplasia of refractory prolymphocytoid variant of B-cell chronic lymphocytic leukemia related to fludarabine treatment." Eur J Haematol 53 (1994): 56-8
Bastion Y, Coiffier B, Tigaud JD, Espinouse D, Bryon PA "Pneumocystis pneumonia in a patient treated with fludarabine for chronic lymphocytic leukemia." Eur J Cancer 27 (1991): 671
"Product Information. Fludara (fludarabine)." Berlex, Richmond, CA.
Leporrier M, Reman O, Troussard X "Pure red-cell aplasia with fludarabine for chronic lymphocytic leukaemia." Lancet 342 (1993): 555
Sanders C, Perez EA, Lawrence HJ "Opportunistic infections in patients with chronic lymphocytic leukemia following treatment with fludarabine." Am J Hematol 39 (1992): 314-5
Girmenia C, Mauro FR, Rahimi S "Late listeriosis after fludarabine plus prednisone treatment." Br J Haematol 87 (1994): 407-8

Fludara

Generic Name: fludarabine

Brand Name: Fludara, Oforta

Synonyms: Fludara (injection)

What is Fludara?