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Flucytosine and Renal dysfunction

Result of checking the interaction of drug Flucytosine and disease Renal dysfunction for safety when used together.

Check result:

Flucytosine <> Renal dysfunction

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Flucytosine must be given with extreme caution to patients with impaired renal function. Flucytosine is excreted primarily by the kidneys, and renal impairment may lead to accumulation of the drug. Serum concentrations of the drug should be monitored to determine the adequacy of renal excretion in such patients. Dosage adjustments should be made in patients with renal insufficiency to prevent progressive accumulation of active drug. Close monitoring of renal, hematologic and hepatic function in all patients is recommended.

References:

Wade DN, Sudlow G "The kinetics of 5-fluorocytosine elimination in man." Aust N Z J Med 2 (1972): 153-8
Drouhet E, Babinet P, Chapusot JP, Kleinknecht D "5-fluorocytosine in the treatment of candidiasis with acute renal insufficiency." Biomedicine 19 (1973): 408-14
"Product Information. Ancobon (flucytosine)." Roche Laboratories, Nutley, NJ.
Cutler RE, Blair AD, Kelly MR "Flucytosine kinetics in subjects with normal and impaired renal function." Clin Pharmacol Ther 24 (1978): 333-42
Lau AH, Kronfol NO "Elimination of flucytosine by continuous hemofiltration." Am J Nephrol 15 (1995): 327-31
Schonebeck J, Polak A, Fernex M, Scholer HJ "Pharmacokinetic studies on the oral antimycotic agent 5-fluorocytosine in individuals with normal and impaired kidney function." Int J Exp Clin Chemother 18 (1973): 321-36
Dawborn JK, Page MD, Schiavone DJ "Use of 5-fluorocytosine in patients with impaired renal function." Br Med J 11/17/73 (1973): 382-4

Flucytosine

Generic Name: flucytosine

Brand Name: Ancobon

Synonyms: n.a.

What is Flucytosine?