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Flecainide Acetate and Renal dysfunction

Result of checking the interaction of drug Flecainide Acetate and disease Renal dysfunction for safety when used together.

Check result:

Flecainide Acetate <> Renal dysfunction

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Flecainide is primarily eliminated by the kidney. Approximately 30% (10% to 50%) of flecainide is excreted in the urine unchanged. The serum concentration of flecainide is increased and the half-life prolonged in patients with renal impairment. Rare conditions such as a strict vegetarian diet or renal tubular acidosis that significantly increase the urinary pH slow the urinary elimination of flecainide. Adjustment of dosage is necessary and modification should be based on the degree of renal impairment. Clinical monitoring of cardiac function (ECG) and renal function is recommended.

References:

Williams AJ, McQuinn RL, Walls J "Pharmacokinetics of flecainide acetate in patients with severe renal impairment." Clin Pharmacol Ther 43 (1988): 449-55
Bailie GR, Waldek S "Pharmacokinetics of flecainide in a patient undergoing continuous ambulatory peritoneal dialysis." J Clin Pharm Ther 13 (1988): 121-4
Forland SC, Cutler RE, McQuinn RL, Kvam DC, Miller AM, Conard GJ, Parish S "Flecainide pharmacokinetics after multiple dosing in patients with impaired renal function." J Clin Pharmacol 28 (1988): 727-35
Hertrampf R, Gundert-Remy U, Beckmann J, et al "Elimination of flecainide as a function of urinary flow rate and pH." Eur J Clin Pharmacol 41 (1991): 61-3
Braun J, Kollert JR, Becker JU "Pharmacokinetics of flecainide in patients with mild and moderate renal failure compared with patients with normal renal function." Eur J Clin Pharmacol 31 (1987): 711-4
Forland SC, Burgess E, Blair AD, et al "Oral flecainide pharmacokinetics in patients with impaired renal function." J Clin Pharmacol 28 (1988): 259-67
Borgeat A, Biollaz J, Freymond B, Bayer-Berger M, Chiolero R "Hemofiltration clearance of flecainide in a patient with acute renal failure." Intensive Care Med 14 (1988): 236-7
Ziegelbaum M, Lever H "Acute urinary retention associated with flecainide." Cleve Clin J Med 57 (1990): 86-7
"Product Information. Tambocor (flecainide)." 3M Pharmaceuticals, St. Paul, MN.

Flecainide Acetate

Generic Name: flecainide

Brand Name: Tambocor

Synonyms: Flecainide

What is Flecainide Acetate?