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Famciclovir and Renal dysfunction

Result of checking the interaction of drug Famciclovir and disease Renal dysfunction for safety when used together.

Check result:

Famciclovir <> Renal dysfunction

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Penciclovir, the active antiviral metabolite of famciclovir, is primarily eliminated by the kidney. Acute renal failure has been reported in patients with underlying renal disease who did not receive an appropriate dosage reduction. Dosage adjustments are recommended for patients with moderate to severe renal impairment (CrCl < 60 mL/min).

References:

Gill KS, Wood MJ "The clinical pharmacokinetics of famciclovir." Clin Pharmacokinet 31 (1996): 1-8
Boike SC, Pue MA, Freed MI, Audet PR, Fairless A, Ilson BE, Zariffa N, Jorkasky DK "Pharmacokinetics of famciclovir in subjects with varying degrees of renal impairment." Clin Pharmacol Ther 55 (1994): 418-26
"Product Information. Famvir (famciclovir)." SmithKline Beecham, Philadelphia, PA.

Famciclovir

Generic Name: famciclovir

Brand Name: Famvir

Synonyms: n.a.

What is Famciclovir?