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Ezetimibe and simvastatin and Myopathy/rhabdomyolysis

Result of checking the interaction of drug Ezetimibe and simvastatin and disease Myopathy/rhabdomyolysis for safety when used together.

Check result:

Ezetimibe and simvastatin <> Myopathy/rhabdomyolysis

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Myopathy and rhabdomyolysis are known adverse reactions to statins and other lipid-lowering drugs. In post-marketing experience with ezetimibe, cases of myopathy and rhabdomyolysis have been reported. Most patients who developed rhabdomyolysis were taking a statin prior to initiating ezetimibe. However, rhabdomyolysis has been reported with ezetimibe monotherapy and with the addition of ezetimibe to agents known to be associated with increased risk of rhabdomyolysis, such as fibrates. In the presence of muscle symptoms and a CPK level >10 × the ULN indicative of myopathy, ezetimibe and any statin or fibrate that the patient is taking concomitantly should be immediately discontinued if myopathy is diagnosed or suspected.

Ezetimibe and simvastatin

Generic Name: ezetimibe / simvastatin

Brand Name: Vytorin

Synonyms: Ezetimibe and Simvastatin

What is Ezetimibe and simvastatin?