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Echothiophate Iodide and Narrow-angle/pupillary block glaucoma

Result of checking the interaction of drug Echothiophate Iodide and disease Narrow-angle/pupillary block glaucoma for safety when used together.

Check result:

Echothiophate Iodide <> Narrow-angle/pupillary block glaucoma

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Miotic agents may cause a paradoxical transient increase in intraocular pressure, which can precipitate an acute attack in patients with angle-closure (narrow-angle) glaucoma or anatomically narrow angles. The risk is much higher with long-acting cholinesterase inhibitors (e.g., demecarium and echothiophate), since these agents can cause pupillary block and increase angle closure. Therapy with long-acting cholinesterase inhibitors should be administered cautiously, or avoided, in patients with chronic angle-closure glaucoma or in patients with anatomically narrow angles. The use of echothiophate iodide is specifically contraindicated in most cases of angle-closure glaucoma. Because chronic use of long-acting cholinesterase inhibitors may cause dilation of blood vessels and increased permeability, these agents should be avoided for at least 2 weeks prior to ophthalmic surgery so as to minimize the risk of hyphema. Miotic agents in general should not be used in patients with glaucoma secondary to unrelieved pupillary block.

References:

Zimmerman TJ, Wheeler TM "Miotics: side effects and ways to avoid them." Ophthalmology 89 (1982): 76-80
"Product Information. Isopto Carpine (pilocarpine ophthalmic)" Alcon Laboratories Inc, Fort Worth, TX.
"Product Information. Isopto Carbachol (carbachol ophthalmic)" Alcon Laboratories Inc, Ft Worth, TX.
"Product Information. Phospholine iodide (echothiophate iodide)." Wyeth-Ayerst Laboratories, Philadelphia, PA.
"Product Information. Eserine (physostigmine ophthalmic)." Ciba Vision Ophthalmics, Duluth, GA.
"Product Information. Humorsol Ophthalmic Solution (demecarium bromide ophthalmic)." Merck & Co, Inc, West Point, PA.
American Medical Association, Division of Drugs and Toxicology "Drug evaluations annual 1994." Chicago, IL: American Medical Association; (1994):

Echothiophate Iodide

Generic Name: echothiophate iodide ophthalmic

Brand Name: Phospholine Iodide

Synonyms: Echothiophate iodide ophthalmic

What is Echothiophate Iodide?