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Dtic-Dome and Hepatic dysfunction

Result of checking the interaction of drug Dtic-Dome and disease Hepatic dysfunction for safety when used together.

Check result:

Dtic-Dome <> Hepatic dysfunction

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

The pharmacokinetic disposition of dacarbazine may be altered in patients with hepatic impairment. Hepatotoxicity, including hepatic vein thrombosis and hepatocellular necrosis, have been reported. Patients should be instructed to immediately report any sign or symptoms of liver dysfunction such as jaundice, dark urine, right upper quadrant pain, or anorexia. Therapy with dacarbazine should be administered cautiously in patients with or predisposed to compromised hepatic function.

References:

Feaux de Lacroix W, Runne U, Hauk H, Doepfmer K, Groth W, Wacker D "Acute liver dystrophy with thrombosis of hepatic veins: a fatal complication of dacarbazine treatment." Cancer Treat Rep 67 (1983): 779-84
"Product Information. DTIC-Dome (dacarbazine)." Bayer, West Haven, CT.
Sutherland CM, Krementz ET "Hepatic toxicity of DTIC." Cancer Treat Rep 65 (1981): 321-2
Marsh JC "Hepatic vascular toxicity of dacarbazine (DTIC): not a rare complication." Hepatology 9 (1989): 790-2

Dtic-Dome

Generic Name: dacarbazine

Brand Name: Dtic-Dome

Synonyms: DTIC-Dome

What is Dtic-Dome?