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Dolutegravir Sodium and Rilpivirine Hydrochloride and Liver impairment

Result of checking the interaction of drug Dolutegravir Sodium and Rilpivirine Hydrochloride and disease Liver impairment for safety when used together.

Check result:

Dolutegravir Sodium and Rilpivirine Hydrochloride <> Liver impairment

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

The effect of severe hepatic impairment (Child - Pugh C) on the pharmacokinetics of dolutegravir has not been studied, therefore dolutegravir is not recommended for use on these patients. No dosage adjustment is needed for patients with mild or moderate hepatic impairment.

Dolutegravir Sodium and Rilpivirine Hydrochloride

Generic Name: dolutegravir / rilpivirine

Brand Name: Juluca

Synonyms: Dolutegravir and rilpivirine, Dolutegravir and Rilpivirine

What is Dolutegravir Sodium and Rilpivirine Hydrochloride?

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Dolutegravir Sodium and Rilpivirine Hydrochloride <> Liver impairment

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

Consumer:

Hepatic adverse events have been reported in patients taking rilpivirine. Patients with underlying hepatitis B or C may be at increased risk for worsening or development of transaminase elevations. A few cases of hepatic toxicity have been reported in patients with no pre-existing hepatic conditions or risk factors. Appropriate laboratory testing prior to treatment and monitoring for hepatotoxicity is recommended, especially in patients with hepatitis B or C or patients with marked elevations in transaminases. The use of rilpivirine has not been studied in patients with severe hepatic impairment (Child Pugh Class C).

Dolutegravir Sodium and Rilpivirine Hydrochloride

Generic Name: dolutegravir / rilpivirine

Brand Name: Juluca

Synonyms: Dolutegravir and rilpivirine, Dolutegravir and Rilpivirine

What is Dolutegravir Sodium and Rilpivirine Hydrochloride?

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