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Disulfiram and Disulfiram reaction

Result of checking the interaction of drug Disulfiram and disease Disulfiram reaction for safety when used together.

Check result:

Disulfiram <> Disulfiram reaction

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

The disulfiram- alcohol reaction may produce symptoms including flushing, throbbing in head and neck, throbbing headache, respiratory difficulty, nausea, vomiting, sweating, thirst, chest pain, palpitation, dyspnea, hyperventilation, tachycardia, hypotension, syncope, weakness, vertigo, blurred vision, and confusion. Severe reactions may result in respiratory depression, cardiovascular collapse, arrhythmias, myocardial infarction, acute congestive heart failure, unconsciousness, convulsions, and death. Because of the possibility of an accidental disulfiram- alcohol reaction, disulfiram should be used with extreme caution in patients with diabetes mellitus, hypothyroidism, seizure disorders, cerebral damage, chronic and acute nephritis, hepatic cirrhosis or insufficiency.

References:

Fernandez D "Another esophageal rupture after alcohol and disulfiram." N Engl J Med 286 (1972): 610
"Product Information. Antabuse (disulfiram)." Wyeth-Ayerst Laboratories, Philadelphia, PA.
Enghusen Poulsen H, Loft S, Andersen JR, Andersen M "Disulfiram therapy--adverse drug reactions and interactions." Acta Psychiatr Scand Suppl 369 (1992): 59-65;
Elenbaas RM "Drug therapy reviews: management of the disulfiram-alcohol reaction." Am J Hosp Pharm 34 (1977): 827-31

Disulfiram

Generic Name: disulfiram

Brand Name: Antabuse

Synonyms: n.a.

What is Disulfiram?