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Disopyramide Phosphate and Sinus-AV node dysfunction

Result of checking the interaction of drug Disopyramide Phosphate and disease Sinus-AV node dysfunction for safety when used together.

Check result:

Disopyramide Phosphate <> Sinus-AV node dysfunction

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

The use of disopyramide is contraindicated in patients with cardiogenic shock, second- or third-degree AV block in the absence of a functional artificial pacemaker, or congenital QT prolongation. Therapy with disopyramide should be administered with extreme caution in patients with sick sinus syndrome (bradycardia-tachycardia), Wolff-Parkinson White syndrome, or bundle-branch block. The effect of disopyramide in these conditions has not been determined.

References:

Desai JM, Scheinman MM, Hirschfeld D, et al "Cardiovascular collapse associated with disopyramide therapy." Chest 79 (1981): 545-51
"Product Information. Norpace (disopyramide)." Searle, Skokie, IL.
Timins BI, Gutman JA, Haft JI "Disopyramide-induced heart block." Chest 79 (1981): 477-9
Timins BI "Disopyramide and bundle-branch block." Ann Intern Med 96 (1982): 684

Disopyramide Phosphate

Generic Name: disopyramide

Brand Name: Norpace, Norpace CR

Synonyms: Disopyramide

What is Disopyramide Phosphate?