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Dimercaprol and Renal dysfunction

Generic Name: dimercaprol
Dosage Forms: n.a.
Other Brand Names: BAL In Oil

Result of checking the interaction of drug Dimercaprol and disease Renal dysfunction for safety when used together.

Check result:

Dimercaprol <> Renal dysfunction

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Dimercaprol is primarily eliminated by the kidney complexed with a heavy metal (lead, arsenic, mercury, gold). Dimercaprol and heavy metals are nephrotoxic and dissociate at an acid pH. Urinary alkalinization during dimercaprol therapy is necessary. The serum concentration of dimercaprol is elevated in patients with oliguria and CNS toxicity and hypertension are possible. Dimercaprol should be discontinued or used only with extreme caution if acute renal insufficiency develops during therapy. Therapy with dimercaprol should be administered very cautiously and dosages reduced in patients with oliguria. Close clinical monitoring of urine pH and renal function is necessary.

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