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Digibind and Renal dysfunction

Result of checking the interaction of drug Digibind and disease Renal dysfunction for safety when used together.

Check result:

Digibind <> Renal dysfunction

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Digoxin immune Fab is eliminated by the kidney complexed to digoxin or digitoxin. The elimination half-life of digoxin immune Fab has not been fully defined, however it is expected to be prolonged in patients with severe renal impairment. It is uncertain if failure to eliminate the complex can lead to reintoxication following the release of complexed digoxin/digitoxin. Therapy with digoxin immune Fab should be administered cautiously in patients with severe renal dysfunction. Clinical monitoring of renal function and symptoms of toxicity should be monitored for an extended time. Digoxin immune Fab interferes with digitalis immunoassay measurements.

References:

Fenton F, Smally AJ, Laut J "Hyperkalemia and digoxin toxicity in a patient with kidney failure." Ann Emerg Med 28 (1996): 440-1
"Product Information. Digibind (digoxin immune FAB)." Glaxo Wellcome, Research Triangle Park, NC.

Digibind

Generic Name: digoxin immune fab

Brand Name: DigiFab, Digibind

Synonyms: n.a.

What is Digibind?