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Akynzeo (Fosnetupitant and Palonosetron) and Severe renal impairment

Result of checking the interaction of drug Akynzeo (Fosnetupitant and Palonosetron) and disease Severe renal impairment for safety when used together.

Check result:
Akynzeo (Fosnetupitant and Palonosetron) <> Severe renal impairment
Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

No dosage adjustment for netupitant/fosnetupitant (only available in combination with palonosetron in the US), is necessary in patients with mild to moderate renal impairment (creatinine clearance of 30 to 60 mL/min). The pharmacokinetics and safety of netupitant/fosnetupitant have not been studied in patients with severe renal impairment. Severe renal impairment (creatinine clearance < 30 mL/min) did not substantially affect pharmacokinetics of palonosetron. The pharmacokinetics for netupitant and palonosetron were not studied in patients with end-stage renal disease requiring hemodialysis, therefore, avoid the use of this drug in patients with severe renal impairment or end-stage renal disease.

Akynzeo (Fosnetupitant and Palonosetron)

Generic Name: fosnetupitant / palonosetron

Brand Name: Akynzeo for injection

Synonyms: Fosnetupitant and palonosetron (injection), Fosnetupitant and Palonosetron

Interaction with food and lifestyle