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Daraprim and Folate deficiency

Result of checking the interaction of drug Daraprim and disease Folate deficiency for safety when used together.

Check result:
Daraprim <> Folate deficiency
Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Pyrimethamine is a folate antagonist. The use of pyrimethamine is contraindicated in patients with megaloblastic anemia caused by folate deficiency. Pyrimethamine should be used with caution in patients with malabsorption syndrome, alcoholism, pregnancy, and in those receiving other folate depleting drugs. Monitoring CBCs and platelet counts are recommended. If signs of folic acid deficiency occur, the drug dosage should be reduced or discontinued. Leucovorin may need to be administered to reverse folic acid deficiency.

References:
  • "Product Information. Daraprim (pyrimethamine)." Glaxo Wellcome, Research Triangle Park, NC.
Daraprim

Generic Name: pyrimethamine

Brand Name: Daraprim

Synonyms: n.a.

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