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Dapsone and Liver disease

Result of checking the interaction of drug Dapsone and disease Liver disease for safety when used together.

Check result:

Dapsone <> Liver disease

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

The use of dapsone has been associated with the development of hyperbilirubinemia. Patients with glucose-6-phosphate dehydrogenase (G-6-PD) deficiency are more likely to develop hyperbilirubinemia. Monitoring liver function is recommended and discontinuation of the drug may be necessary.

References:

May DG, Arns PA, Richards WO, et al "The disposition of dapsone in cirrhosis." Clin Pharmacol Ther 51 (1992): 689-700
Mills J, Leoung G, Ileana M, Hopewell PC, Hughes WT, Wofsy C "Dapsone treatment of pneumocystis carinii pneumonia in the acquired immunodeficiency syndrome." Antimicrob Agents Chemother 32 (1988): 1057-60
Fleming CM, Branch RA, Wilkinson GR, Guengerich FP "Human liver microsomal N-hydroxylation of dapsone by cytochrome P-4503A4." Mol Pharmacol 41 (1992): 975-80
"Product Information. Dapsone USP (dapsone)." Jacobus Pharmaceutical Company, Princeton, NJ.
Beumont MG, Graziani A, Ubel PA, Macgregor RR "Safety of dapsone as pneumocystis carinii pneumonia prophylaxis in human immunodeficiency virus-infected patients with allergy to trimethoprim/sulfamethoxazole." Am J Med 100 (1996): 611-6

Dapsone

Generic Name: dapsone

Brand Name:

Synonyms: Dapsone (Systemic)

What is Dapsone?