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Coreg CR and Liver disease

Result of checking the interaction of drug Coreg CR and disease Liver disease for safety when used together.

Check result:

Coreg CR <> Liver disease

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Carvedilol is extensively metabolized by the liver. Patients with cirrhosis have demonstrated significantly higher plasma concentrations (approximately 4 to 7-fold) of carvedilol compared to healthy individuals. The use of carvedilol is contraindicated in patients with severe hepatic impairment.

References:

Neugebauer G, Akpan W, von Mollendorff E, Neubert P, Reiff K "Pharmacokinetics and disposition of carvedilol in humans." J Cardiovasc Pharmacol 10 Suppl 1 (1987): s85-8
Neugebauer G, Neubert P "Metabolism of carvedilol in man." Eur J Drug Metab Pharmacokinet 16 (1991): 257-60
Neugebauer G, Gabor M, Reiff K "Pharmacokinetics and bioavailability of carvedilol in patients with liver cirrhosis." Drugs 36 Suppl 6 (1988): 148-54
"Product Information. Coreg (carvedilol)." SmithKline Beecham, Philadelphia, PA.
Neugebauer G, Gabor M, Reiff K "Disposition of carvedilol enantiomers in patients with liver cirrhosis: evidence for disappearance of stereoselective first-pass extraction." J Cardiovasc Pharmacol 19 Suppl 1 (1992): s142-6

Coreg CR

Generic Name: carvedilol

Brand Name: Coreg, Coreg CR

Synonyms: n.a.

What is Coreg CR?