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Colchicine Tablets and Liver disease

Result of checking the interaction of drug Colchicine Tablets and disease Liver disease for safety when used together.

Check result:

Colchicine Tablets <> Liver disease

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

The clearance of colchicine may be significantly reduced and plasma half-life prolonged in patients with chronic hepatic impairment compared to healthy subject. No pharmacokinetic data are available for patients with severe hepatic impairment (Child-Pugh C). Caution is recommended when prescribing colchicine to these patients.

References:

Stanley MW, Taurog JD, Snover DC "Fatal colchicine toxicity: report of a case." Clin Exp Rheumatol 2 (1984): 167-71
Zifroni A, Schaffner F "Long-term follow-up of patients with primary biliary cirrhosis on colchicine therapy." Hepatology 14 (1991): 990-3
Caraco Y, Putterman C, Rahamimov R, Ben-Chetrit E "Acute colchicine intoxication: possible role of erythromycin administration." J Rheumatol 19 (1992): 494-6
Leighton JA, Bay MK, Maldonado AL, Schenker S, Speeg KV "Colchicine clearance is impaired in alcoholic cirrhosis." Hepatology 14 (1991): 1013-5
"Product Information. Colchicine (colchicine)." Lilly, Eli and Company, Indianapolis, IN.
Warnes TW, Smith A, Lee FI, Haboubi NY, Johnson PJ, Hunt L "A controlled trial of colchicine in primary biliary cirrhosis. Trial design and preliminary report." J Hepatol 5 (1987): 1-7
Kocak N, Yuce A, Gurakan F, Ozen H, Gogus S, Kale G, Caglar M "Colchicine in the treatment of hepatic fibrosis in children." Am J Gastroenterol 91 (1996): 179-80

Colchicine Tablets

Generic Name: colchicine

Brand Name: Colcrys, Mitigare

Synonyms: Colchicine

What is Colchicine Tablets?