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Coartem and Hepato/renal impairment

Result of checking the interaction of drug Coartem and disease Hepato/renal impairment for safety when used together.

Check result:

Coartem <> Hepato/renal impairment

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

The pharmacokinetics of artemether have not been studied in patients with either hepatic or renal impairment. Additionally, the efficacy and safety of the drug has not been studied in patients with severe hepatic and/or renal impairment. No dose adjustment is recommended for patients with renal impairment as there is no or insignificant renal excretion of lumefantrine, artemether and dihydroartemisinin (DHA), an active antimalarial metabolite of artemether. No dosage adjustment is necessary in patients with mild to moderate hepatic impairment. Caution should be exercised when administering lumefantrine and artemether to patients with severe hepatic or renal impairment. Close monitoring is recommended.

Coartem

Generic Name: artemether / lumefantrine

Brand Name: Coartem

Synonyms: n.a.

What is Coartem?