Drug search by name

Chloral Hydrate Syrup and Renal/liver disease

Result of checking the interaction of drug Chloral Hydrate Syrup and disease Renal/liver disease for safety when used together.

Check result:

Chloral Hydrate Syrup <> Renal/liver disease

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

The use of chloral hydrate is contraindicated in patients with marked renal and/or hepatic impairment due to the potential for significant drug and metabolite accumulation. Chloral hydrate is metabolized by the liver and erythrocytes to the pharmacologically active compound, trichloroethanol (TCE), which has a plasma half-life of 8 to 12 hours. TCE is then metabolized further by both the liver and kidney to inactive substances that are slowly excreted in the urine. High plasma levels of chloral hydrate and TCE may produce respiratory depression and adverse cardiovascular effects such as peripheral vasodilation, hypotension, arrhythmias, and myocardial depression.

References:

Muller G, Spassovski M, Henschler D "Metabolism of trichloroethylene in man: pharmacokinetics of metabolites." Arch Toxicol 32 (1974): 283-95
Garrett ER, Lambert HJ "Pharmacokinetics of trichloroethanol and metabolites and interconversions among variously referenced pharmacokinetic parameters." J Pharm Sci 62 (1973): 550-72
"Product Information. Aquachloral Supprettes (chloral hydrate)." Medisca, Plattsburg, NY.

Chloral Hydrate Syrup

Generic Name: chloral hydrate

Brand Name: Somnote

Synonyms: Chloral Hydrate Capsules

What is Chloral Hydrate Syrup?