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Ceftolozane Sulfate and Tazobactam Sodium and Renal impairment

Result of checking the interaction of drug Ceftolozane Sulfate and Tazobactam Sodium and disease Renal impairment for safety when used together.

Check result:

Ceftolozane Sulfate and Tazobactam Sodium <> Renal impairment

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Ceftolozane, tazobactam and the tazobactam metabolite M1 are eliminated from the body by renal excretion. In a subgroup analysis of a Phase 3 cIAI trial, clinical cure rates were lower in patients with baseline creatinine clearance (CrCl) of 30 to <=50 mL/min compared to those with CrCl >50 mL/min. Dosage adjustment is required in patients with moderate (CrCl 30 to 50 mL/min) or severe (CrCl 15 to 29 mL/min) renal impairment and in patients with ESRD on HD as per manufacturer recommendations. For patients with changing renal function, monitor CrCl at least daily and adjust the dosage of the compound accordingly.

Ceftolozane Sulfate and Tazobactam Sodium

Generic Name: ceftolozane / tazobactam

Brand Name: Zerbaxa

Synonyms: Ceftolozane and tazobactam, Ceftolozane and Tazobactam

What is Ceftolozane Sulfate and Tazobactam Sodium?