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Busulfan Concentrate Injection and Myelosuppression

Result of checking the interaction of drug Busulfan Concentrate Injection and disease Myelosuppression for safety when used together.

Check result:

Busulfan Concentrate Injection <> Myelosuppression

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Busulfan induces severe and prolonged myelosuppression at the recommended dosage. Hematopoietic progenitor cell transplantation is required to prevent potentially fatal complications of the prolonged myelosuppression. It is recommended to closely monitor complete blood counts, including white blood cell differentials, and quantitative platelet counts daily during treatment and until engraftment is demonstrated. Extreme caution should be exercised if busulfan is administered in patients whose bone marrow reserve may be compromised by prior irradiation or chemotherapy or whose marrow function is recovering from previous cytotoxic therapy. Patients should be instructed to immediately report any signs or symptoms suggesting bone marrow suppression, such as fever, sore throat, local infection, bleeding, or symptoms of anemia.

References:

Fernandez LA, Zayed E "Busulfan-induced sideroblastic anemia." Am J Hematol 28 (1988): 199-200
"Product Information. Myleran (busulfan)." Prasco Laboratories, Cincinnati, OH.

Busulfan Concentrate Injection

Generic Name: busulfan

Brand Name: Busulfex, Myleran

Synonyms: Busulfan (oral/injection), Busulfan

What is Busulfan Concentrate Injection?