Bisoprolol and Hydrochlorothiazide and Renal/liver disease
Result of checking the interaction of drug Bisoprolol and Hydrochlorothiazide and disease Renal/liver disease for safety when used together.
When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.
Consumer:Bisoprolol is eliminated by both the kidney and liver. Patients with renal and/or liver disease may be at greater risk for adverse effects from bisoprolol due to decreased drug clearance. Initial dosage adjustments and cautious titration are recommended in patients with a creatinine clearance below 40 mL/min and/or liver disease.
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- "Product Information. Zebeta (bisoprolol)." Lederle Laboratories, Wayne, NJ.
- Payton CD, Fox JG, Pauleau NF, Boulton-Jones JM, Ioannides C, Johnston A, Thomas P "The single dose pharmacokinetics of bisoprolol (10 mg) in renal insufficiency: the clinical significance of balanced clearance." Eur Heart J 8 (1987): 15-22
Generic Name: bisoprolol / hydrochlorothiazide
Brand Name: Ziac
Synonyms: Hydrochlorothiazide and bisoprolol