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Bismuth subcitrate potassium, metronidazole, and tetracycline and Liver disease

Result of checking the interaction of drug Bismuth subcitrate potassium, metronidazole, and tetracycline and disease Liver disease for safety when used together.

Check result:

Bismuth subcitrate potassium, metronidazole, and tetracycline <> Liver disease

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Metronidazole is extensively metabolized by the liver to both pharmacologically active and inactive compounds. The plasma clearance of metronidazole may be decreased and the half-life prolonged in patients with impaired hepatic function. Therapy with metronidazole should be administered cautiously at reduced dosages in patients with severe liver disease.

References:

Loft S, Dossing M, Poulsen HE, et al "Influence of dose and route of administration on disposition of metronidazole and its major metabolites." Eur J Clin Pharmacol 30 (1986): 467-73
"Product Information. Flagyl (metronidazole)." Searle, Skokie, IL.
Loft S, Sonne J, Dossing M, Andreasen PB "Metronidazole pharmacokinetics in patients with hepatic encephalopathy." Scand J Gastroenterol 22 (1987): 117-23
Jensen JC, Gugler R "Single- and multiple-dose metronidazole kinetics." Clin Pharmacol Ther 34 (1983): 481-7
Lau AH, Evans R, Chang CW, Seligsohn R "Pharmacokinetics of metronidazole in patients with alcoholic liver disease." Antimicrob Agents Chemother 31 (1987): 1662-4
Farrell G, Baird-Lambert J, Cvejic M, Buchanan N "Disposition and metabolism of metronidazole in patients with liver failure." Hepatology 4 (1984): 772-6

Bismuth subcitrate potassium, metronidazole, and tetracycline

Generic Name: bismuth subcitrate potassium / metronidazole / tetracycline

Brand Name: Pylera

Synonyms: Bismuth Subcitrate, Metronidazole, and Tetracycline

What is Bismuth subcitrate potassium, metronidazole, and tetracycline?