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Zanosar and Renal dysfunction

Result of checking the interaction of drug Zanosar and disease Renal dysfunction for safety when used together.

Check result:

Zanosar <> Renal dysfunction

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Renal toxicity reported during streptozocin therapy is dose-related, cumulative, and may be severe or fatal. The use of streptozocin in patients with renal disease requires a judgment by the physician of potential benefit as opposed to the known risk of serious renal damage. If the need outweighs the risk, extreme caution should be exercised in administering streptozocin and therapy should be initiated at a reduced dosage. Close clinical monitoring of renal function such as serial urinalysis, BUN, serum creatinine, creatinine clearance, and serum electrolytes prior to and after each course of streptozocin therapy is recommended. Development of significant renal toxicity may require a reduction in dose or discontinuation of streptozocin therapy.

References:

"Product Information. Zanosar (streptozocin)." Pharmacia and Upjohn, Kalamazoo, MI.
Perry DJ, Weiss RB "Nephrotoxicity of streptozocin." Ann Intern Med 96 (1982): 122

Zanosar

Generic Name: streptozocin

Brand Name: Zanosar

Synonyms: n.a.

What is Zanosar?