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Zaleplon and Liver disease

Result of checking the interaction of drug Zaleplon and disease Liver disease for safety when used together.

Check result:

Zaleplon <> Liver disease

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Zaleplon is primarily metabolized by the liver. The oral clearance of zaleplon has been shown to decrease by 70% and 87% in patients with compensated and decompensated cirrhosis, respectively, compared to healthy patients. Associated plasma drug concentrations were markedly increased by several-fold. Therapy with zaleplon is not recommended in patients with severely impaired hepatic function. The dosage should be reduced to 5 mg in patients with mild to moderate hepatic impairment.

References:

Dooley M, Plosker GL "Zaleplon - A review of its use in the treatment of insomnia." Drugs 60 (2000): 413-45
"Product Information. Sonata (zaleplon)" Wyeth-Ayerst Laboratories, Philadelphia, PA.

Zaleplon

Generic Name: zaleplon

Brand Name: Sonata

Synonyms: n.a.

What is Zaleplon?

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