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BACiiM and Renal dysfunction

Result of checking the interaction of drug BACiiM and disease Renal dysfunction for safety when used together.

Check result:

BACiiM <> Renal dysfunction

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

The systemic use of bacitracin is contraindicated in patients with elevated BUN or nonprotein nitrogen or other evidence of renal impairment. Bacitracin is highly nephrotoxic and may cause glomerular and tubular necrosis, manifested initially by albuminuria, hematuria, cylindruria, and rising blood concentrations of the drug, then eventually by oliguria, azotemia, and renal failure. Bacitracin-induced nephrotoxicity is related to the total daily dosage and the duration of administration. To minimize the risk of toxicity, patients should be adequately hydrated, urine should be alkalinized to pH 6 or greater, the usual dosage should not be exceeded, and use with other nephrotoxic agents should be avoided. Renal function should be closely monitored, and therapy withdrawn promptly if toxicity develops.

References:

"Product Information. Bacitracin (bacitracin)." Pharmacia and Upjohn, Kalamazoo, MI.
American Medical Association, Division of Drugs and Toxicology "Drug evaluations annual 1994." Chicago, IL: American Medical Association; (1994):

BACiiM

Generic Name: bacitracin

Brand Name: Baci-IM, Baci-Rx

Synonyms: Baci-IM (injection)

What is BACiiM?