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Vorinostat and Liver impairment

Result of checking the interaction of drug Vorinostat and disease Liver impairment for safety when used together.

Check result:

Vorinostat <> Liver impairment

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Compared to patients with normal liver function, AUC increases of 50 to 66% were observed in patients with hepatic impairment. It is recommended to reduce the starting dose of vorinostat to 300 mg orally once daily with food in patients with mild to moderate hepatic impairment (bilirubin 1 to 3 × ULN or AST greater than ULN). There is insufficient evidence to recommend a starting dose for patients with severe hepatic impairment (bilirubin greater than 3 × ULN). Precautions should be instituted when using this agent in patients with liver dysfunction.

Vorinostat

Generic Name: vorinostat

Brand Name: Zolinza

Synonyms: n.a.

What is Vorinostat?