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Vasopressin (IM or Subcutaneous) and Fluid overload/hyponatremia

Result of checking the interaction of drug Vasopressin (IM or Subcutaneous) and disease Fluid overload/hyponatremia for safety when used together.

Check result:

Vasopressin (IM or Subcutaneous) <> Fluid overload/hyponatremia

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Water intoxication and hyponatremia may occur during therapy with vasopressin or desmopressin due to their antidiuretic action. Patients are most likely to experience this problem if their fluid intake is excessive or if they do not require antidiuresis, such as when they are administered these agents for their hemostatic effects. Fluid intake should be adjusted carefully to avoid overhydration, particularly in children, elderly, and patients with conditions that may be exacerbated by fluid retention, including epilepsy, migraine, asthma, and heart failure. Patients should be monitored for signs of water intoxication (e.g., listlessness, drowsiness, and headaches), which may rarely progress to seizures and coma. The use of desmopressin is contraindicated in patients with hyponatremia or a history of hyponatremia.

References:

"Product Information. Pitressin (vasopressin)." Parke-Davis, Morris Plains, NJ.
Robson WLM, Norgaard JP, Leung AKC "Hyponatremia in patients with nocturnal enuresis treated with DDAVP." Eur J Pediatr 155 (1996): 959-62
"Product Information. Stimate (desmopressin)." Forest Pharmaceuticals, St. Louis, MO.
"Product Information. DDAVP (desmopressin)." Rhone-Poulenc Rorer, Collegeville, PA.
Williford SL "Water intoxication in patients treated with desmopressin - reply." Pharmacotherapy 16 (1996): 970
Lin TW, Kuo YS "Acute pulmonary oedema following administration of vasopressin for control of massive GI tract haemorrhage in a major burn patient." Burns 22 (1996): 73-5
Tulandi T, Beique F, Kimia M "Pulmonary edema: a complication of local injection of vasopressin at laparoscopy." Fertil Steril 66 (1996): 478-80
Robson WLM "Water intoxication in patients treated with desmopressin." Pharmacotherapy 16 (1996): 969-70

Vasopressin (IM or Subcutaneous)

Generic Name: vasopressin

Brand Name: Vasostrict, Pitressin, Pitressin Synthetic

Synonyms: Vasopressin

What is Vasopressin (IM or Subcutaneous)?