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Valtrex and Hemodialysis

Result of checking the interaction of drug Valtrex and disease Hemodialysis for safety when used together.

Check result:

Valtrex <> Hemodialysis

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Valacyclovir is almost completely converted in vivo to acyclovir, which is substantially removed by hemodialysis. Plasma levels of acyclovir have been shown to reduce by 60% following 6 hours of dialysis. Valacyclovir should be administered after hemodialysis. Otherwise, an additional dose may be given after each hemodialysis session.

References:

Krasny HC, Liao SH, de Miranda P, Laskin OL, Whelton A, Lietman PS "Influence of hemodialysis on acyclovir pharmacokinetics in patients with chronic renal failure." Am J Med 73 (1982): 202-4
Laskin OL, Longstreth JA, Whelton A, et al "Acyclovir kinetics in end-stage renal disease." Clin Pharmacol Ther 31 (1982): 594-600
"Product Information. Valtrex (valacyclovir)." Glaxo Wellcome, Research Triangle Park, NC.

Valtrex

Generic Name: valacyclovir

Brand Name: Valtrex

Synonyms: n.a.

What is Valtrex?