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Triamterene and Hydrochlorothiazide Capsules and Folate antagonism

Result of checking the interaction of drug Triamterene and Hydrochlorothiazide Capsules and disease Folate antagonism for safety when used together.

Check result:

Triamterene and Hydrochlorothiazide Capsules <> Folate antagonism

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Triamterene is a weak folate antagonist and may contribute to megaloblastic anemia in cases where folic acid stores have been depleted. Therapy with triamterene should be administered cautiously in patients with or predisposed to megaloblastic anemia, including cirrhotic patients with splenomegaly. These patients should be observed for exacerbations of underlying liver disease during triamterene therapy.

References:

Corcino J, Waxman S, Herbert V "Mechanism of triamterene-induced megaloblastosis." Ann Intern Med 73 (1970): 419-24
Lieberman FL, Bateman JR "Megaloblastic anemia possibly induced by triamterene in patients with alcoholic cirrhosis. Two case reports." Ann Intern Med 68 (1968): 168-73
"Product Information. Dyrenium (triamterene)." SmithKline Beecham, Philadelphia, PA.

Triamterene and Hydrochlorothiazide Capsules

Generic Name: hydrochlorothiazide / triamterene

Brand Name: Dyazide, Maxzide, Maxzide-25

Synonyms: Hydrochlorothiazide and triamterene, Hydrochlorothiazide and Triamterene

What is Triamterene and Hydrochlorothiazide Capsules?