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Trabectedin and Hepatotoxicity

Result of checking the interaction of drug Trabectedin and disease Hepatotoxicity for safety when used together.

Check result:

Trabectedin <> Hepatotoxicity

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Hepatotoxicity, including hepatic failure, can occur with the use of trabectedin. It is recommended to assess liver function test (LFTs) prior to each administration of trabectedin and as deem appropriately based on the severity of preexisting hepatic impairment. Dose interruption, reduction, or discontinuation of treatment might be appropriate based on severity and duration of LFTs abnormality. The use of trabectedin in patients with mild hepatic impairment is not expected to cause clinically significant effects on its pharmacokinetics. Reduce dose in patients with moderate hepatic impairment as clinically appropriate and do not administer trabectedin to patients with severe hepatic impairment (bilirubin levels above 3 times to 10 times the upper limit of normal, and any AST and ALT). Close monitoring of LFTs is recommended.

Trabectedin

Generic Name: trabectedin

Brand Name: Yondelis

Synonyms: n.a.

What is Trabectedin?