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Tisagenlecleucel and Infections

Result of checking the interaction of drug Tisagenlecleucel and disease Infections for safety when used together.

Check result:

Tisagenlecleucel <> Infections

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Drugs directed against B cells, such as axicabtagene ciloleucel, and tisagenlecleucel should not be administered to patients with clinically significant active systemic infections. Severe or life-threatening infections, including febrile neutropenia, were observed in patients after treatment with these agents and may be concurrent with Cytokine Release Syndrome (CRS). It is recommended to monitor patients for signs and symptoms of infection before and after infusion and administer prophylactic antimicrobials as appropriate. Counsel patients to seek immediate medical attention should signs, or symptoms of CRS occur at any time. At the first sign of CRS, institute treatment with supportive care according to medical practices.

Tisagenlecleucel

Generic Name: tisagenlecleucel

Brand Name: Kymriah

Synonyms: n.a.

What is Tisagenlecleucel?