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Tiagabine and Liver disease

Generic Name: tiagabine
Dosage Forms: n.a.
Other Brand Names: Gabitril

Result of checking the interaction of drug Tiagabine and disease Liver disease for safety when used together.

Check result:

Tiagabine <> Liver disease

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Tiagabine is extensively metabolized by the liver. In patients with moderately impaired hepatic function (Child-Pugh Class B), the clearance of unbound tiagabine was reduced by about 60%. Therapy with tiagabine should be administered cautiously in patients with liver disease. Reduced dosages and/or longer dosing intervals may be necessary in these patients.

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