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Terbinafine (Systemic) and Liver disease

Result of checking the interaction of drug Terbinafine (Systemic) and disease Liver disease for safety when used together.

Check result:

Terbinafine (Systemic) <> Liver disease

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Oral terbinafine is not recommended for use in patients with chronic or active liver disease. Terbinafine may be hepatotoxic. Rare cases of cholestatic hepatitis and liver failure, some resulting in liver transplant or death, have been reported during treatment of various dermatologic conditions in patients with and without preexisting liver disease. Although a causal relationship has not been established, the severity of hepatic events and/or their outcome may be worse in patients with active or chronic liver disease.

References:

Lowe G, Green C, Jennings P "Hepatitis associated with terbinafine treatment." BMJ 306 (1993): 248
"Product Information. Lamisil (terbinafine)." Sandoz Pharmaceuticals Corporation, East Hanover, NJ.
Balfour JA, Faulds D "Terbinafine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in superficial mycoses [published erratum appears in Drugs 1992 May;43(5):699]." Drugs 43 (1992): 259-84
Lazaros GA, Papatheodoridis GV, Delladetsima JK, Tassopoulos NC "Terbinafine-induced cholestatic liver disease." J Hepatol 24 (1996): 753-6

Terbinafine (Systemic)

Generic Name: terbinafine

Brand Name: Lamisil, Terbinex

Synonyms: Terbinafine

What is Terbinafine (Systemic)?