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Tegaserod and Liver disease

Generic Name: tegaserod
Dosage Forms: n.a.
Other Brand Names: Zelnorm

Result of checking the interaction of drug Tegaserod and disease Liver disease for safety when used together.

Check result:

Tegaserod <> Liver disease

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

The use of tegaserod is contraindicated in patients with moderate or severe hepatic impairment, as it has not been adequately studied for treatment in this population. In subjects with mild hepatic impairment, mean peak plasma concentration (Cmax) and area under the concentration-time curve (AUC) of tegaserod were 16% and 31% higher, respectively, compared to subjects with normal hepatic function. No dosage adjustment is required in patients with mild hepatic impairment; however, caution is advised when using tegaserod in such patients.

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