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Sodium Phenylbutyrate Powder and Fluid retention

Result of checking the interaction of drug Sodium Phenylbutyrate Powder and disease Fluid retention for safety when used together.

Check result:
Sodium Phenylbutyrate Powder <> Fluid retention
Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

The use of sodium phenylbutyrate may cause fluid retention in patients with congestive heart failure, renal dysfunction, or sodium retention with edema. Sodium phenylbutyrate is primarily excreted by the kidney and these patients may exhibit reduced excretion. Therapy with sodium phenylbutyrate should be administered cautiously in these patients. Monitoring plasma levels of ammonia, arginine, branched-chain amino acids and serum proteins to maintain within normal limits and glutamine to less than 1000 mcmol/L is recommended.

References:
  • "Product Information. Buphenyl (sodium phenylbutyrate)." Horizon Pharma USA Inc, Northbrook, IL.
Sodium Phenylbutyrate Powder

Generic Name: sodium phenylbutyrate

Brand Name: Buphenyl

Synonyms: Sodium phenylbutyrate

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