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Seromycin and CNS toxicity

Generic Name: cycloserine
Dosage Forms: capsule
Other Brand Names: Seromycin

Result of checking the interaction of drug Seromycin and disease CNS toxicity for safety when used together.

Check result:

Seromycin <> CNS toxicity

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

The use of cycloserine is contraindicated in patients with seizure disorders, depression, severe anxiety, dementia, psychoses, and alcoholism. Cycloserine is associated with a high incidence of dose-related central nervous system (CNS) toxicities, including confusion, disorientation, aggression, anxiety, psychoses, depression with suicidal tendencies, paresis, seizures, and coma. CNS effects may be more likely to occur with dosages greater than 500 mg/day, in chronic alcoholics, and during coadministration with ethionamide or isoniazid. Toxicity correlates with blood levels exceeding 30 mcg/mL.

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