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Sargramostim Powder for Injection and Prematurity

Result of checking the interaction of drug Sargramostim Powder for Injection and disease Prematurity for safety when used together.

Check result:

Sargramostim Powder for Injection <> Prematurity

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

The use of Leukine (brand of sargramostim) liquid or lyophilized powder reconstituted with Bacteriostatic Water for Injection is considered by the drug manufacturer to be contraindicated in neonates, particularly premature infants and infants of low birth weight. These preparations contain benzyl alcohol which, in bacteriostatic saline intravascular flush and endotracheal tube lavage solutions, has been associated with fatalities and severe respiratory and metabolic complications in low-birth-weight premature infants. However, many experts feel that, in the absence of benzyl alcohol- free equivalents, the amount of the preservative present in these formulations should not necessarily preclude their use if they are clearly indicated. The American Academy of Pediatrics considers benzyl alcohol in low doses (such as when used as a preservative in some medications) to be safe for newborns. Continuous infusions of high dosages of medications containing benzyl alcohol may, however, cause toxicity and should be avoided if possible.

References:

""Inactive" ingredients in pharmaceutical products: update (subject review). American Academy of Pediatrics Committee on Drugs. Available from: URL: http://www.aap.org/policy/re9706.html." Pediatrics 99 (1997): 268-78
"Product Information. Leukine (sargramostim)." Immunex Corporation, Seattle, WA.
"Product Information. Prokine (sargramostim)." Hoechst Marion-Roussel Inc, Kansas City, MO.

Sargramostim Powder for Injection

Generic Name: sargramostim

Brand Name: Leukine

Synonyms: Sargramostim

What is Sargramostim Powder for Injection?