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Rythmol and Liver disease

Result of checking the interaction of drug Rythmol and disease Liver disease for safety when used together.

Check result:

Rythmol <> Liver disease

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Propafenone is extensively metabolized by the liver. The bioavailability of propafenone in patients with normal hepatic function is approximately 3% to 40%, but increases to approximately 70% in patients with severe hepatic impairment. Therapy with propafenone should be administered cautiously and the dosage reduced to 20% to 30% of that given patients with normal hepatic function. Clinical monitoring of cardiac function (ECG) and hepatic function is recommended.

References:

Spinler SA, Elder CA, Kindwall KE "Propafenone-induced liver injury." Ann Pharmacother 26 (1992): 926-8
"Product Information. Rhythmol (propafenone)." Knoll Pharmaceutical Company, Whippany, NJ.
Mondardini A, Pasquino P, Bernardi P, Aluffi E, Tartaglino B, Mazzucco G, Bonino F, Verme G, Negro F "Propafenone-induced liver injury: report of a case and review of the literature." Gastroenterology 104 (1993): 1524-6

Rythmol

Generic Name: propafenone

Brand Name: Rythmol, Rythmol SR

Synonyms: n.a.

What is Rythmol?