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Rimantadine and Liver disease

Result of checking the interaction of drug Rimantadine and disease Liver disease for safety when used together.

Check result:

Rimantadine <> Liver disease

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Rimantadine is primarily metabolized by the liver. Patients with liver disease may be at greater risk for adverse effects from rimantadine due to decreased drug clearance. Therapy with rimantadine should be administered cautiously in patients with liver disease. One-half the usual dosage is recommended for patients with severe hepatic dysfunction.

References:

Wills RJ, Belshe R, Tomlinsin D, De Grazia F, Lin A, Wells S, Milazzo J, Berry C "Pharmacokinetics of rimantadine hydrochloride in patients with chronic liver disease." Clin Pharmacol Ther 42 (1987): 449-54
"Product Information. Flumadine (rimantadine)." Forest Pharmaceuticals, St. Louis, MO.

Rimantadine

Generic Name: rimantadine

Brand Name: Flumadine

Synonyms: n.a.

What is Rimantadine?