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Rifaximin and Liver disease

Result of checking the interaction of drug Rifaximin and disease Liver disease for safety when used together.

Check result:

Rifaximin <> Liver disease

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Rifaximin is metabolized by the liver. Following administration of rifaximin 550 mg twice daily to patients with a history of hepatic encephalopathy, systemic exposure (AUC) was about 10-, 13- and 20- fold higher in patients with mild (Child-Pugh A), moderate (Child-Pugh B) and severe (Child-Pugh C) hepatic impairment, respectively, compared to that in healthy volunteers. Animal toxicity studies did not achieve systemic exposures that were seen in patients with severe hepatic impairment, thus clinical significance is unknown. No dosage adjustment is recommended because systemic absorption of rifaximin is presumably limited. Nonetheless, therapy with rifaximin should be administered cautiously in patients with severe hepatic impairment.

Rifaximin

Generic Name: rifaximin

Brand Name: Xifaxan

Synonyms: n.a.

What is Rifaximin?